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Article

Oncogene and therapeutic target analyses in atypical fibroxanthomas and pleomorphic dermal sarcomas.

Oncotarget - 19 Apr 2016

Helbig Doris, Ihle Michaela Angelika, Pütz Katharina, Tantcheva-Poor Iliana, Mauch Cornelia, Büttner Reinhard, Quaas Alexander

Abstract excerpt

BACKGROUND: Until now, almost nothing is known about the tumorigenesis of atypical fibroxanthoma (AFX) and pleomorphic dermal sarcoma (PDS). Our hypothesis is that AFX is the non-infiltrating precursor lesion of PDS. MATERIALS AND METHODS: We performed the world-wide most comprehensive immunohistochemical and mutational analysis in well-defined AFX (n=5) and PDS (n=5). RESULTS: In NGS-based mutation analyses of...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26943575
DOI: 10.18632/oncotarget.7845
PMCID: PMC5008321

Genes

CCND1
CDK4
HRAS
IMP3
CTNNB1
EGFR
EPCAM
ERBB2
FGFR1
FGFR2
FGFR3
KIT
KNSTRN
MDM2
MET
MKI67
MYC
SOX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Oncogene and therapeutic target analyses in atypical fibroxanthomas and pleomorphic dermal sarcomas.PMID 26943575Read ↗

Mutational profile of atypical fibroxanthoma and pleomorphic dermal sarcoma further expands the spectrum of genomic alterations in rare cutaneous neoplasms.Semantic proximity Read ↗

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Molecular Characterization of Atypical Fibroxanthoma and Pleomorphic Dermal SarcomaSemantic proximity Read ↗

Atypical fibroxanthoma and pleomorphic dermal sarcoma harbor frequent NOTCH1/2 and FAT1 mutations and similar DNA copy number alteration profiles.Semantic proximity Read ↗

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