Cutaneous Epithelioid/Pleomorphic Rhabdomyosarcoma, Melanoma in Disguise? An Immunohistochemical, Molecular, and Epigenetic Study of 13 Patients.

doi:10.1016/j.modpat.2026.100983

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Article

Cutaneous Epithelioid/Pleomorphic Rhabdomyosarcoma, Melanoma in Disguise? An Immunohistochemical, Molecular, and Epigenetic Study of 13 Patients.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 May 2026

Ulici Veronica, Ameline Baptiste, John Ivy, Dermawan Josephine K, Karunamurthy Arivarasan, Dehner Carina A, Fernandez Anthony P, Azzato Elizabeth, Hattery Travis, Kilpatrick Scott E, Isaacson Alexandra L, Ko Jennifer S, Fritchie Karen J, Baumhoer Daniel, Billings Steven D

Abstract excerpt

Rhabdomyosarcomatous transdifferentiation is a rare but well-documented phenomenon in melanoma, and, in these cases, recognition of a conventional component by either morphology or immunophenotype is essential for the correct diagnosis. However, tumors that are entirely transdifferentiated can be impossible to distinguish from primary rhabdomyosarcoma. We analyzed a cohort of cases diagnosed as cutaneous...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 41780801
DOI: 10.1016/j.modpat.2026.100983

Genes

BRAF
NRAS
HRAS
TFCP2

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