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Article

Atypical fibroxanthoma and pleomorphic dermal sarcoma harbor frequent NOTCH1/2 and FAT1 mutations and similar DNA copy number alteration profiles.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Mar 2018

Griewank Klaus G, Wiesner Thomas, Murali Rajmohan, Pischler Carina, Müller Hansgeorg, Koelsche Christian, Möller Inga, Franklin Cindy, Cosgarea Ioana, Sucker Antje, Schadendorf Dirk, Schaller Jörg, Horn Susanne, Brenn Thomas, Mentzel Thomas

Abstract excerpt

Atypical fibroxanthomas and pleomorphic dermal sarcomas are tumors arising in sun-damaged skin of elderly patients. They have differing prognoses and are currently distinguished using histological criteria, such as invasion of deeper tissue structures, necrosis and lymphovascular or perineural invasion. To investigate the as-yet poorly understood genetics of these tumors, 41 atypical fibroxanthomas and 40...

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Identifiers

PMID: 29099504
DOI: 10.1038/modpathol.2017.146
PMCID: PMC7463132

Genes

FAT1
NOTCH1
TERT

Provenance

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Atypical fibroxanthoma and pleomorphic dermal sarcoma harbor frequent NOTCH1/2 and FAT1 mutations and similar DNA copy number alteration profiles.PMID 29099504Read ↗

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