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GRIN2B Promoter Methylation Deficits in Early-Onset Schizophrenia and its Association with Cognitive Function

20 Feb 2019

Abstract excerpt

AIM: We investigated GRIN1 and GRIN2B promoter methylation in first-episode schizophrenia patients compared with siblings and controls, testing for correlations between DNA methylation, cognitive performance and clinical variables. MATERIALS & METHODS: Blood-derived DNA from all groups underwent bisulfite conversion and pyrosequencing to determine methylation at CpG sites within the GRIN1 and GRIN2B promoters and...

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PMID: 30785307
DOI: 10.2217/epi-2018-0127

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