Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association between GRIN2B DNA methylation and cognitive impairment: a cross-sectional study of patients with bipolar depression

14 May 2025

Abstract excerpt

Background: Cognitive impairment is a prevalent feature throughout the course of bipolar disorder (BD) and may contribute to recurrent episodes and poor prognosis. Despite its significant clinical impact, the biological mechanisms underlying cognitive impairment in BD remain poorly understood, complicating treatment efforts. The NR2B subunit of the N-methyl-D-aspartate (NMDA) receptor, encoded by the GRIN2B gene,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bipolar Disorder and Treatment
Share to Epigenetics and DNA Methylation
Share to Phosphodiesterase function and regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40438331
DOI: 10.3389/fpsyt.2025.1574391

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association between GRIN2B DNA methylation and cognitive impairment: a cross-sectional study of patients with bipolar depressionPMID 40438331Read ↗

GRIN2B Promoter Methylation Deficits in Early-Onset Schizophrenia and its Association with Cognitive FunctionSemantic proximity Read ↗

GRIN2B gene and associated brain cortical white matter changes in bipolar disorder: a preliminary combined platform investigation.Semantic proximity Read ↗

Genetic impact of ZNF804A on cognitive function in patients with bipolar I disorder.Semantic proximity Read ↗

Combined effect of genetic variants in the GluN2B coding gene (GRIN2B) on prefrontal function during working memory performance.Semantic proximity Read ↗

Impact of GRIK4 gene polymorphisms on cognitive dysfunction in patients with major depression.Semantic proximity Read ↗

Decreased DNA methylation at promoters and gene-specific neuronal hypermethylation in the prefrontal cortex of patients with bipolar disorderSemantic proximity Read ↗

Childhood adversity increases methylation in the GRIN2B geneSemantic proximity Read ↗

Decreased DNA methylation at promoters and gene-specific neuronal hypermethylation in the prefrontal cortex of patients with bipolar disorderSemantic proximity Read ↗

N-methyl-D-aspartate receptor NR2B subunit gene GRIN2B in schizophrenia and bipolar disorder: Polymorphisms and mRNA levels.Semantic proximity Read ↗

Functional human GRIN2B promoter polymorphism and variation of mental processing speed in older adults.Semantic proximity Read ↗

Dissect the Heterogeneity of Longitudinal Cognitive Declines with Risk Factors and Functional Outcomes in Bipolar DisorderSemantic proximity Read ↗

Reduced expression of N-methyl-D-aspartate receptor and calcium signaling genes in gray matter is associated with cognitive function in patients with breast cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.