Article
GRIN2A null variants confer a high risk for early-onset schizophrenia and other mental disorders and potentially enable precision therapy.
Molecular psychiatry - 1 Jan 2026
Lemke Johannes R, Eoli Andrea, Krey Ilona, Popp Bernt, Strehlow Vincent, Wittekind Dirk A, Vuorinen Anna-Leena, Aldhalaan Hesham M, Baer Sarah, de Saint Martin Anne, Hammer Trine B, Herman Isabella, Hornemann Frauke, Ingebrigtsen Trine, Lederer Damien, Lesca Gaetan, Marafie Dana, Mathot Mikael, Rosenfeld Jill A, Møller Rikke S, Schelhaas Helenius J, Stillman Chelsey, Orsini Alessandro, Patel Anup D, Piard Juliette, Veggiotti Pierangelo, Vlaskamp Danique R M, Weckhuysen Sarah, Traynelis Stephen F, Benke Tim A, Heyne Henrike O, Syrbe Steffen
Abstract excerpt
Rare genetic factors have been shown to substantially contribute to mental illness, but so far, no precision treatments for mental disorders have been described. It was recently identified that rare variants in GRIN2A encoding the GluN2A subunit of the N-methyl-D-aspartate receptor (NMDAR) confer a substantial risk for schizophrenia. To determine the prevalence of mental disorders among individuals with...
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