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Article

Telomerase-deficient mice exhibit bone loss owing to defects in osteoblasts and increased osteoclastogenesis by inflammatory microenvironment.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Jul 2011

Saeed Hamid, Abdallah Basem M, Ditzel Nicholas, Catala-Lehnen Philip, Qiu Weimin, Amling Michael, Kassem Moustapha

Abstract excerpt

Telomere shortening owing to telomerase deficiency leads to accelerated senescence of human skeletal (mesenchymal) stem cells (MSCs) in vitro, whereas overexpression leads to telomere elongation, extended life span, and enhanced bone formation. To study the role of telomere shortening in vivo, we...

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Identifiers

PMID: 21308778
DOI: 10.1002/jbmr.349

Genes

MSC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21308778-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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