1,25‐Dihydroxyvitamin D protects against age‐related osteoporosis by a novel VDR‐Ezh2‐p16 signal axis

Abstract excerpt

Abstract To determine whether 1,25‐dihydroxyvitamin D (1,25(OH) 2 D) can exert an anti‐osteoporosis role through anti‐aging mechanisms, we analyzed the bone phenotype of mice with 1,25(OH) 2 D deficiency due to deletion of the enzyme, 25‐hydroxyvitamin D 1α‐hydroxylase, while on a rescue diet. 1,25(OH) 2 D deficiency accelerated age‐related bone loss by activating the p16/p19 senescence signaling pathway,...

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