Article
Evidence for the evolutionary steps leading to mecA-mediated β-lactam resistance in staphylococci.
PLoS genetics - 1 Apr 2017
Rolo Joana, Worning Peder, Boye Nielsen Jesper, Sobral Rita, Bowden Rory, Bouchami Ons, Damborg Peter, Guardabassi Luca, Perreten Vincent, Westh Henrik, Tomasz Alexander, de Lencastre Hermínia, Miragaia Maria
Abstract excerpt
The epidemiologically most important mechanism of antibiotic resistance in Staphylococcus aureus is associated with mecA-an acquired gene encoding an extra penicillin-binding protein (PBP2a) with low affinity to virtually all β-lactams. The introduction of mecA into the S. aureus chromosome has led to the emergence of methicillin-resistant S. aureus (MRSA) pandemics, responsible for high rates of mortality...
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