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Article

Regulation of Gene Expression by 1α,25-Dihydroxyvitamin D<sub>3</sub>and Its Analog EB1089 under Growth-Inhibitory Conditions in Squamous Carcinoma Cells

1 Jul 2001

Abstract excerpt

Analogs of 1alpha,25-dihydroxyvitamin D(3) (1alpha, 25(OH)2D3) inhibit growth in vitro and in vivo of cells derived from a variety of tumors. Here, we examined the effects of 1alpha,25(OH)2D3 and its analog EB1089 on proliferation and target gene regulation of human head and neck squamous cell carcinoma (SCC) lines SCC4, SCC9, SCC15, and SCC25. A range of sensitivities to 1alpha,25(OH)2D3 and EB1089 was observed,...

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PMID: 11435613
DOI: 10.1210/mend.15.7.0655

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