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The DNA mismatch repair gene hMSH2 is a potent coactivator of oestrogen receptor α

10 May 2005

Abstract excerpt

The DNA mismatch repair gene is a key regulator in the elimination of base-base mismatches and insertion/deletion loops (IDLs). Human MutS homologue 2 (hMSH2), originally identified as a human homologue of the bacterial MutS, is a tumour suppressor gene frequently mutated in hereditary non-polyposis colorectal cancer. Hereditary non-polyposis colorectal cancer is characterised by the early onset of colorectal...

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PMID: 15886699
DOI: 10.1038/sj.bjc.6602614

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