Article
Growth hormone is permissive for neoplastic colon growth.
Proceedings of the National Academy of Sciences of the United States of America - 7 Jun 2016
Chesnokova Vera, Zonis Svetlana, Zhou Cuiqi, Recouvreux Maria Victoria, Ben-Shlomo Anat, Araki Takako, Barrett Robert, Workman Michael, Wawrowsky Kolja, Ljubimov Vladimir A, Uhart Magdalena, Melmed Shlomo
Abstract excerpt
Growth hormone (GH) excess in acromegaly is associated with increased precancerous colon polyps and soft tissue adenomas, whereas short-stature humans harboring an inactivating GH receptor mutation do not develop cancer. We show that locally expressed colon GH is abundant in conditions predisposing to colon cancer and in colon adenocarcinoma-associated stromal fibroblasts. Administration of a GH receptor (GHR)...
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