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Article

Requirement of Bardet-Biedl syndrome proteins for leptin receptor signaling

15 Jan 2009

Abstract excerpt

Obesity is a major public health problem in most developed countries and a major risk factor for diabetes and cardiovascular disease. Emerging evidence indicates that ciliary dysfunction can contribute to human obesity but the underlying molecular and cellular mechanisms are unknown. Bardet-Biedl syndrome (BBS) is a genetically heterogeneous human obesity syndrome associated with ciliary dysfunction. BBS proteins...

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PMID: 19150989
DOI: 10.1093/hmg/ddp031

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Requirement of Bardet-Biedl syndrome proteins for leptin receptor signalingPMID 19150989Read ↗

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Bardet-Biedl syndrome 3 (Bbs3) knockout mouse model reveals common BBS-associated phenotypes and Bbs3 unique phenotypes.Semantic proximity Read ↗

A knockin mouse model of the Bardet-Biedl syndrome 1 M390R mutation has cilia defects, ventriculomegaly, retinopathy, and obesity.Semantic proximity Read ↗

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