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Article

Neither signal transducer and activator of transcription 3 (STAT3) or STAT5 signaling pathways are required for leptin's effects on fertility in mice.

Endocrinology - 1 Jul 2013

Singireddy Amritha V, Inglis Megan A, Zuure Wieteke A, Kim Joon S, Anderson Greg M

Abstract excerpt

The hormone leptin is critical for the regulation of energy balance and fertility. The long-form leptin receptor (LepR) regulates multiple intracellular signaling cascades, including the classic Janus kinase-signal transducer and activator of transcription (STAT) pathways. Previous studies have shown that deletion of STAT3 or the closely related STAT5 from the brain results in an obese phenotype, but their roles...

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Identifiers

PMID: 23696567
DOI: 10.1210/en.2013-1109

Genes

STAT3

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