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Article

Defective STAT signaling by the leptin receptor in diabetic mice.

25 Jun 1996

Abstract excerpt

Leptin and its receptor, obese receptor (OB-R), comprise an important signaling system for the regulation of body weight. Splice variants of OB-R mRNA encode proteins that differ in the length of their cytoplasmic domains. We cloned a long isoform of the wild-type leptin receptor that is preferentially expressed in the hypothalamus and show that it can activate signal transducers and activators of transcription...

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Identifiers

PMID: 8692797
DOI: 10.1073/pnas.93.13.6231

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