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Defining the Transcriptional Targets of Leptin Reveals a Role for Atf3 in Leptin Action

13 Mar 2018

Abstract excerpt

Leptin acts via its receptor (LepRb) to modulate gene expression in hypothalamic LepRb-expressing neurons, thereby controlling energy balance and glucose homeostasis. Despite the importance of the control of gene expression in hypothalamic LepRb neurons for leptin action, the transcriptional targets of LepRb signaling have remained undefined because LepRb cells contribute a small fraction to the aggregate...

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PMID: 29535089
DOI: 10.2337/db17-1395

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