Article
Modulating microglia activation prevents maternal immune activation induced schizophrenia-relevant behavior phenotypes via arginase 1 in the dentate gyrus.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Oct 2020
Xia Yucen, Zhang Zhiqing, Lin Weipeng, Yan Jinglan, Zhu Chuan'an, Yin Dongmin, He Su, Su Yang, Xu Nenggui, Caldwell Robert William, Yao Lin, Chen Yongjun
Abstract excerpt
Prenatal infection during pregnancy increases the risk for developing neuropsychiatric disorders such as schizophrenia. This is linked to an inflammatory microglial phenotype in the offspring induced by maternal immune activation (MIA). Microglia are crucial for brain development and maintenance of neuronal niches, however, whether and how their activation is involved in the regulation of neurodevelopment remains...
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