Article

Effects of prenatal maternal immune activation and exposure to circadian disruption during adolescence: exploring the two-hit model of neurodevelopmental disorders

2024-02-28

Abstract excerpt

<h4>Background</h4> Around 80% of individuals with neurodevelopmental disorders (NDDs) such as schizophrenia and autism spectrum disorders experience disruptions in sleep/circadian rhythms. We explored whether prenatal infection, an established risk factor for NDDs, and environmental circadian disruption synergistically induced sex-specific deficits in mice. <h4>Methods</h4> A maternal immune activation (MIA) pr...

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Literature Corpus work: fd739203-8b30-5bd2-9edb-81760767501f
DOI: 10.1101/2024.02.25.580567

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