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Paternal high molecular weight poly I:C administration alters the sperm small non-coding RNA profile and offspring brain development and behavioural phenotype.

Brain, behavior, and immunity - 1 Aug 2026

van de Garde Nicholas, Meng Qi, Dontamsetti Ganani, Kiridena Pamudika, Lu Da, Masson Bethany A, Adithya Pranav, Liao Huan, Reisinger Sonali N, Hannan Anthony J

Abstract excerpt

Paternal immune activation (PIA), including via the viral mimic polyinosinic:polycytidylic acid (poly I:C), impacts offspring physiology and behaviour. A previous model employing low molecular weight (LMW) poly I:C showed alterations in the sperm small non-coding RNA (sncRNA) profile and offspring phenotypes. High molecular weight (HMW) poly I:C increases translatability by eliciting a robust sickness response...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42002009
DOI: 10.1016/j.bbi.2026.106599

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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