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Histone Modifications and the Maintenance of Telomere Integrity

25 Feb 2019

Abstract excerpt

Telomeres, the nucleoprotein structures at the ends of eukaryotic chromosomes, play an integral role in protecting linear DNA from degradation. Dysregulation of telomeres can result in genomic instability and has been implicated in increased rates of cellular senescence and many diseases, including cancer. The integrity of telomeres is maintained by a coordinated network of proteins and RNAs, such as the...

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PMID: 30823596
DOI: 10.3390/cells8020199

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