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Aging-Associated Alteration of Telomere Length and Subtelomeric Status in Female Patients With Parkinson's Disease

27 Feb 2012

Abstract excerpt

A telomere is a repetitive DNA structure at chromosomal ends that stabilizes the chromosome structure and prevents harmful end-to-end recombinations. The telomere length of somatic cells becomes shorter with aging because of the "end replication problem." This telomere shortening is accelerated by pathophysiological conditions including daily mental stress. Living with Parkinson's disease (PD) causes physical and...

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PMID: 22364520
DOI: 10.3109/01677063.2011.651665

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