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DNA methylation variations and epigenetic aging in telomere biology disorders

16 May 2023

Abstract excerpt

Telomere Biology Disorders (TBDs) are characterized by mutations in telomere-related genes leading to short telomeres and premature aging but with no strict correlation between telomere length and disease severity. Epigenetic alterations are also markers of aging and we aimed to evaluate whether DNA methylation (DNAm) could be part of the pathogenesis of TBDs. In blood from 35 TBD cases, genome-wide DNAm were...

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Share to Epigenetics and DNA Methylation
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PMID: 37193737
DOI: 10.1038/s41598-023-34922-1

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