Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Intratumor DNA methylation heterogeneity in glioblastoma: implications for DNA methylation-based classification

14 Jan 2019

Abstract excerpt

BACKGROUND: A feature of glioblastoma (GBM) is cellular and molecular heterogeneity, both within and between tumors. This variability causes a risk for sampling bias and potential tumor escape from future targeted therapy. Heterogeneous intratumor gene expression in GBM is well documented, but little is known regarding the epigenetic heterogeneity. Variability in DNA methylation within tumors would have...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caveolin-1 and cellular processes
Share to Epigenetics and DNA Methylation
Share to Glioma Diagnosis and Treatment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30668814
DOI: 10.1093/neuonc/noz011

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Intratumor DNA methylation heterogeneity in glioblastoma: implications for DNA methylation-based classificationPMID 30668814Read ↗

Intratumoral heterogeneity identified at the epigenetic, genetic and transcriptional level in glioblastomaSemantic proximity Read ↗

Methylation subgroup and molecular heterogeneity is a hallmark of glioblastoma: implications for biopsy targeting, classification and therapySemantic proximity Read ↗

Spatial heterogeneity in DNA methylation and chromosomal alterations in diffuse gliomas and meningiomas.Semantic proximity Read ↗

The DNA methylation landscape of glioblastoma disease progression shows extensive heterogeneity in time and spaceSemantic proximity Read ↗

Molecular heterogeneity of glioblastoma and its clinical relevance.Semantic proximity Read ↗

Analysis of gliomas DNA methylation: Assessment of pre-analytical variablesSemantic proximity Read ↗

Histologically defined intratumoral sequencing uncovers evolutionary cues into conserved molecular events driving gliomagenesisSemantic proximity Read ↗

Methylation profiling identifies 2 groups of gliomas according to their tumorigenesis.Semantic proximity Read ↗

Loss of 5-hydroxymethylcytosine and intratumoral heterogeneity as an epigenomic hallmark of glioblastoma.Semantic proximity Read ↗

DNA methylation heterogeneity attributable to a complex tumor immune microenvironment prompts prognostic risk in glioma.Semantic proximity Read ↗

MGMT and Whole-Genome DNA Methylation Impacts on Diagnosis, Prognosis and Therapy of Glioblastoma Multiforme.Semantic proximity Read ↗

Molecular subtypes of glioblastoma are relevant to lower grade glioma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.