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Article

Spatial heterogeneity in DNA methylation and chromosomal alterations in diffuse gliomas and meningiomas.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Nov 2022

Ferreyra Vega Sandra, Wenger Anna, Kling Teresia, Olsson Bontell Thomas, Jakola Asgeir Store, Carén Helena

Abstract excerpt

Adult-type diffuse gliomas and meningiomas are the most common primary intracranial tumors of the central nervous system. DNA methylation profiling is a novel diagnostic technique increasingly used also in the clinic. Although molecular heterogeneity is well described in these tumors, DNA methylation heterogeneity is less studied. We therefore investigated the intratumor genetic and epigenetic heterogeneity in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35701666
DOI: 10.1038/s41379-022-01113-8
PMCID: PMC9596370

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