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Article

DNA methylation heterogeneity attributable to a complex tumor immune microenvironment prompts prognostic risk in glioma.

Epigenetics - 1 Dec 2024

Ma Shuangyue, Pan Xu, Gan Jing, Guo Xiaxin, He Jiaheng, Hu Haoyu, Wang Yuncong, Ning Shangwei, Zhi Hui

Abstract excerpt

Gliomas are malignant tumours of the human nervous system with different World Health Organization (WHO) classifications, glioblastoma (GBM) with higher grade and are more malignant than lower-grade glioma (LGG). To dissect how the DNA methylation heterogeneity in gliomas is influenced by the complex cellular composition of the tumour immune microenvironment, we first compared the DNA methylation profiles of...

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Identifiers

PMID: 38439715
DOI: 10.1080/15592294.2024.2318506
PMCID: PMC10936651

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