Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Suppression of eEF2 phosphorylation alleviates synaptic failure and cognitive deficits in mouse models of Down syndrome

27 Jun 2024

Abstract excerpt

INTRODUCTION: Cognitive impairment is a core feature of Down syndrome (DS), and the underlying neurobiological mechanisms remain unclear. Translation dysregulation is linked to multiple neurological disorders characterized by cognitive impairments. Phosphorylation of the translational factor eukaryotic elongation factor 2 (eEF2) by its kinase eEF2K results in inhibition of general protein synthesis. METHODS: We...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related gene regulation
Share to Down syndrome and intellectual disability research
Share to Signaling Pathways in Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 38934363
DOI: 10.1002/alz.13916

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Suppression of eEF2 phosphorylation alleviates synaptic failure and cognitive deficits in mouse models of Down syndromePMID 38934363Read ↗

Antagonists targeting eEF2 kinase rescue multiple aspects of pathophysiology in Alzheimer’s disease model miceSemantic proximity Read ↗

Antagonists targeting eEF2 kinase rescue multiple aspects of pathophysiology in Alzheimer’s disease model miceSemantic proximity Read ↗

Genetic reduction of eEF2 kinase alleviates pathophysiology in Alzheimer’s disease model miceSemantic proximity Read ↗

Activation of the ISR mediates the behavioral and neurophysiological abnormalities in Down syndromeSemantic proximity Read ↗

Protein Dynamics Associated with Failed and Rescued Learning in the Ts65Dn Mouse Model of Down SyndromeSemantic proximity Read ↗

Ts65Dn synaptic proteome partially recapitulates AD biochemical signatureSemantic proximity Read ↗

Challenges and Opportunities for Translation of Therapies to Improve Cognition in Down Syndrome.Semantic proximity Read ↗

Loss of Correlations among Proteins in Brains of the Ts65Dn Mouse Model of Down SyndromeSemantic proximity Read ↗

Glutamatergic synaptic deficits in the prefrontal cortex of the Ts65Dn mouse model for Down syndromeSemantic proximity Read ↗

DYRK1A, a Dosage-Sensitive Gene Involved in Neurodevelopmental Disorders, Is a Target for Drug Development in Down SyndromeSemantic proximity Read ↗

Overexpression of Dyrk1A Is Implicated in Several Cognitive, Electrophysiological and Neuromorphological Alterations Found in a Mouse Model of Down SyndromeSemantic proximity Read ↗

The eIF4E homolog 4EHP (eIF4E2) regulates hippocampal long-term depression and impacts social behavior.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.