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Article

Epigenetic Silencing Affects l -Asparaginase Sensitivity and Predicts Outcome in T-ALL

18 Jan 2019

Abstract excerpt

Abstract Purpose: Biological explanation for discrepancies in patient-related response to chemotherapy depending on the underlying oncogenic events is a promising research area. TLX1- or TLX3-deregulated T-cell acute lymphoblastic leukemias (T-ALL; TLX1/3+) share an immature cortical phenotype and similar transcriptional signatures. However, their prognostic impacts differ, and inconsistent clinical outcome has...

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PMID: 30659025
DOI: 10.1158/1078-0432.ccr-18-1844

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Epigenetic Silencing Affects l -Asparaginase Sensitivity and Predicts Outcome in T-ALLPMID 30659025Read ↗

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