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Article

Asparagine synthetase as a causal, predictive biomarker for l -asparaginase activity in ovarian cancer cells

1 Nov 2006

Abstract excerpt

L-Asparaginase (l-ASP), a bacterial enzyme used since the 1970s to treat acute lymphoblastic leukemia, selectively starves cells that cannot synthesize sufficient asparagine for their own needs. Molecular profiling of the NCI-60 cancer cell lines using five different microarray platforms showed strong negative correlations of asparagine synthetase (ASNS) expression and DNA copy number with sensitivity to l-ASP in...

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PMID: 17088436
DOI: 10.1158/1535-7163.mct-06-0447

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