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Article

Association of allele-specific methylation of the ASNS gene with asparaginase sensitivity and prognosis in T-ALL.

Blood advances - 11 Jan 2022

Akahane Koshi, Kimura Shunsuke, Miyake Kunio, Watanabe Atsushi, Kagami Keiko, Yoshimura Kentaro, Shinohara Tamao, Harama Daisuke, Kasai Shin, Goi Kumiko, Kawai Tomoko, Hata Kenichiro, Kiyokawa Nobutaka, Koh Katsuyoshi, Imamura Toshihiko, Horibe Keizo, Look A Thomas, Minegishi Masayoshi, Sugita Kanji, Takita Junko, Inukai Takeshi

Abstract excerpt

Asparaginase therapy is a key component of chemotherapy for patients with T-cell acute lymphoblastic leukemia (T-ALL). Asparaginase depletes serum asparagine by deamination into aspartic acid. Normal hematopoietic cells can survive due to asparagine synthetase (ASNS) activity, whereas leukemia cells are supposed to undergo apoptosis due to silencing of the ASNS gene. Because the ASNS gene has a typical CpG island...

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Identifiers

PMID: 34535013
DOI: 10.1182/bloodadvances.2021004271
PMCID: PMC8753197

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