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Clonal haematopoiesis: a source of biological noise in cell-free DNA analyses

8 Jan 2019

Abstract excerpt

There is considerable interest in the development of a blood-based biomarker for early-cancer detection driven by an important clinical need; to detect cancers earlier when cure is feasible. A low false-positive rate is a vital component of any diagnostic assay being leveraged in an early-detection setting [1]. Cell-free circulating tumour DNA (ctDNA) is an analyte within blood that holds potential as a highly...

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PMID: 30649226
DOI: 10.1093/annonc/mdy552

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