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Article

The ctDNA Paradigm: Dynamic Observation, Quantitative Analysis, and Interpretive Limits in Precision Oncology.

Genes - 30 Jun 2026

Chetta Massimiliano, Bukvic Nenad, Rosati Alessandra

Abstract excerpt

Circulating tumor DNA (ctDNA) was initially conceived as a minimally invasive surrogate for interrogating cancer biology; however, three decades of evidence have demonstrated that plasma is not a passive reservoir of tumor-derived material, but rather a dynamic and biologically heterogeneous milieu in which multiple competing genomic signals coexist. This review explores the level of interpretive rigor required...

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Identifiers

PMID: 42510794
DOI: 10.3390/genes17070754
PMCID: PMC13408779

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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