Article

Regulation of essential hepatocyte functions and identity by super-enhancers in health and disease

2025-06-07

Abstract excerpt

Physiologically, hepatocytes perform an estimated 500 essential liver functions to ensure systemic homeostasis. The mechanisms how hepatocytes maintain these numerous crucial functions in response to physiological and pathophysiological challenges are largely unknown. In this study, we found that vital liver function genes (e.g., HNF4A , ALB , coagulation factors, and SLC2A2 ) in hepatocytes possess super-enhan...

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Literature Corpus work: d0b266e4-4f53-5d99-8e0e-b4dc535a16c4
DOI: 10.1101/2025.06.04.657826

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