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Article

Defective HNF4alpha-dependent gene expression as a driver of hepatocellular failure in alcoholic hepatitis

16 Jul 2019

Abstract excerpt

Alcoholic hepatitis (AH) is a life-threatening condition characterized by profound hepatocellular dysfunction for which targeted treatments are urgently needed. Identification of molecular drivers is hampered by the lack of suitable animal models. By performing RNA sequencing in livers from patients with different phenotypes of alcohol-related liver disease (ALD), we show that development of AH is characterized...

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PMID: 31311938
DOI: 10.1038/s41467-019-11004-3

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