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Interference with the HNF4-dependent gene regulatory network diminishes endoplasmic reticulum stress in hepatocytes

11 Oct 2023

Abstract excerpt

BACKGROUND: In all eukaryotic cell types, the unfolded protein response (UPR) upregulates factors that promote protein folding and misfolded protein clearance to help alleviate endoplasmic reticulum (ER) stress. Yet, ER stress in the liver is uniquely accompanied by the suppression of metabolic genes, the coordination and purpose of which are largely unknown. METHODS: Here, we combined in silico machine learning,...

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PMID: 37820274
DOI: 10.1097/hc9.0000000000000278

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