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Article

Chemical interference with DSIF complex formation lowers synthesis of mutant huntingtin gene products and curtails mutant phenotypes.

Proceedings of the National Academy of Sciences of the United States of America - 9 Aug 2022

Deng Ning, Wu Yun-Yun, Feng Yanan, Hsieh Wen-Chieh, Song Jen-Shin, Lin Yu-Shiuan, Tseng Ya-Hsien, Liao Wan-Jhu, Chu Yi-Fan, Liu Yu-Cheng, Chang En-Cheng, Liu Chia-Rung, Sheu Sheh-Yi, Su Ming-Tsan, Kuo Hung-Chih, Cohen Stanley N, Cheng Tzu-Hao

Abstract excerpt

Earlier work has shown that siRNA-mediated reduction of the SUPT4H or SUPT5H proteins, which interact to form the DSIF complex and facilitate transcript elongation by RNA polymerase II (RNAPII), can decrease expression of mutant gene alleles containing nucleotide repeat expansions differentially. Using luminescence and fluorescence assays, we identified chemical compounds that interfere with the SUPT4H-SUPT5H...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35914128
DOI: 10.1073/pnas.2204779119
PMCID: PMC9371670

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