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Article

Spt4 selectively regulates the expression of <i>C9orf72</i> sense and antisense mutant transcripts

11 Aug 2016

Abstract excerpt

An expanded hexanucleotide repeat in C9orf72 causes amyotrophic lateral sclerosis and frontotemporal dementia (c9FTD/ALS). Therapeutics are being developed to target RNAs containing the expanded repeat sequence (GGGGCC); however, this approach is complicated by the presence of antisense strand transcription of expanded GGCCCC repeats. We found that targeting the transcription elongation factor Spt4 selectively...

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PMID: 27516603
DOI: 10.1126/science.aaf7791

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