Article

Defective Integrator activity shapes the transcriptome of patients with multiple sclerosis

2023-11-24

Abstract excerpt

HP1α/CBX5 is an epigenetic regulator with a suspected role in multiple sclerosis (MS). Here, using high-depth RNA sequencing on monocytes, we identified a subset of MS patients with reduced CBX5 expression, correlating with progressive stages of the disease and extensive transcriptomic alterations. Examination of rare non-coding RNA species in these patients revealed impaired maturation/degradation of U snRNAs and...

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Literature Corpus work: c1ccd447-37e8-5453-96d6-59b72f257539
DOI: 10.1101/2023.11.24.568591

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