Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Active Kras Expression in Gastric Isthmal Progenitor Cells Induces Foveolar Hyperplasia but Not Metaplasia

18 Sept 2018

Abstract excerpt

Two types of metaplasia are associated with the development of intestinal-type cancers in the human stomach: intestinal metaplasia and spasmolytic polypeptide (Trefoil Factor 2 [TFF2])-expressing metaplasia (SPEM). Previous investigations have noted activation of RAS protein in up to 40% of human gastric cancer patients.1 Our recent results using the Mist1CreERT;Kras LSL-G12D mice, expressing constitutively...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Galectins and Cancer Biology
Share to Helicobacter pylori-related gastroenterology studies
Share to Pancreatic and Hepatic Oncology Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30585163
DOI: 10.1016/j.jcmgh.2018.09.007

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Active Kras Expression in Gastric Isthmal Progenitor Cells Induces Foveolar Hyperplasia but Not MetaplasiaPMID 30585163Read ↗

Expression of Activated Ras in Gastric Chief Cells of Mice Leads to the Full Spectrum of Metaplastic Lineage Transitions.Semantic proximity Read ↗

<i>Tff2</i> marks gastric corpus progenitors that give rise to pyloric metaplasia/SPEM following injurySemantic proximity Read ↗

Three types of metaplasia model through Kras activation, Pten deletion, or Cdh1 deletion in the gastric epithelium.Semantic proximity Read ↗

Isthmus Stem Cells Are the Origins of Metaplasia in the Gastric CorpusSemantic proximity Read ↗

Biology of intestinal metaplasia in 2008: more than a simple phenotypic alteration.Semantic proximity Read ↗

Single-cell profiling uncovers a <i>Muc4</i> -expressing metaplastic gastric cell type sustained by <i>Helicobacter pylori</i> -specific inflammationSemantic proximity Read ↗

Stomach-Specific Activation of Oncogenic KRAS and STAT3-Dependent Inflammation Cooperatively Promote Gastric Tumorigenesis in a Preclinical ModelSemantic proximity Read ↗

Spasmolytic polypeptide‐expressing metaplasia ( SPEM ) cell lineages can be an origin of gastric cancerSemantic proximity Read ↗

Activating KRAS and GNAS mutations in heterotopic submucosal glands of the stomach.Semantic proximity Read ↗

Single-cell Profiling Uncovers a Muc4 -Expressing Metaplastic Gastric Cell Type Sustained by Helicobacter pylori -driven InflammationSemantic proximity Read ↗

Mature gastric chief cells are not required for the development of metaplasiaSemantic proximity Read ↗

Metaplastic Cells in the Stomach Arise, Independently of Stem Cells, via Dedifferentiation or Transdifferentiation of Chief Cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.