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Article

Metaplastic Cells in the Stomach Arise, Independently of Stem Cells, via Dedifferentiation or Transdifferentiation of Chief Cells.

Gastroenterology - 1 Mar 2018

Radyk Megan D, Burclaff Joseph, Willet Spencer G, Mills Jason C

Abstract excerpt

Spasmolytic polypeptide-expressing metaplasia (SPEM) develops in patients with chronic atrophic gastritis due to infection with Helicobacter pylori; it might be a precursor to intestinal metaplasia and gastric adenocarcinoma. Lineage tracing experiments of the gastric corpus in mice have not established whether SPEM derives from proliferating stem cells or differentiated, post-mitotic zymogenic chief cells in the...

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Identifiers

PMID: 29248442
DOI: 10.1053/j.gastro.2017.11.278
PMCID: PMC5847468

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