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Spasmolytic polypeptide‐expressing metaplasia ( SPEM ) cell lineages can be an origin of gastric cancer

5 May 2023

Abstract excerpt

Intestinal-type gastric cancer arises in a field of precancerous metaplastic lineages. Two types of metaplastic glands are found in the stomachs of humans with the characteristics of pyloric metaplasia or intestinal metaplasia. While spasmolytic polypeptide-expressing metaplasia (SPEM) cell lineages have been identified in both pyloric metaplasia and incomplete intestinal metaplasia, it has been unclear whether...

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PMID: 37145865
DOI: 10.1002/path.6089

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