Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Three types of metaplasia model through Kras activation, Pten deletion, or Cdh1 deletion in the gastric epithelium.

The Journal of pathology - 1 Jan 2019

Kinoshita Hiroto, Hayakawa Yoku, Konishi Mitsuru, Hata Masahiro, Tsuboi Mayo, Hayata Yuki, Hikiba Yohko, Ihara Sozaburo, Nakagawa Hayato, Ikenoue Tsuneo, Ushiku Tetsuo, Fukayama Masashi, Hirata Yoshihiro, Koike Kazuhiko

Abstract excerpt

Chronic inflammation and intestinal metaplasia are strongly associated with gastric carcinogenesis. Kras activation and Pten deletion are observed in intestinal-type gastric cancer, and Cdh1 mutation is associated with diffuse-type gastric cancer. Although various mouse models of gastric carcinogenesis have been reported, few mouse lines enable gene manipulation selectively in the stomach. Here we established a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cadherins
Share to Chromosomes, Artificial, Bacterial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gastric Mucosa

Share to Gastritis

Share to Integrases

Share to Metaplasia

Share to PTEN Phosphohydrolase

Share to Tissue Culture Techniques

Source

Identifiers

PMID: 30168144
DOI: 10.1002/path.5163

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Three types of metaplasia model through Kras activation, Pten deletion, or Cdh1 deletion in the gastric epithelium.PMID 30168144Read ↗

Expression of Activated Ras in Gastric Chief Cells of Mice Leads to the Full Spectrum of Metaplastic Lineage Transitions.Semantic proximity Read ↗

Precancerous pathways to gastric cancer: a review of experimental animal models recapitulating the correa cascadeSemantic proximity Read ↗

Single-cell profiling uncovers a <i>Muc4</i> -expressing metaplastic gastric cell type sustained by <i>Helicobacter pylori</i> -specific inflammationSemantic proximity Read ↗

Stomach-Specific Activation of Oncogenic KRAS and STAT3-Dependent Inflammation Cooperatively Promote Gastric Tumorigenesis in a Preclinical ModelSemantic proximity Read ↗

Mouse Models of Gastric CancerSemantic proximity Read ↗

Oncogenic KRAS and p53 Loss Drive Gastric Tumorigenesis in Mice That Can Be Attenuated by E-Cadherin ExpressionSemantic proximity Read ↗

Active Kras Expression in Gastric Isthmal Progenitor Cells Induces Foveolar Hyperplasia but Not MetaplasiaSemantic proximity Read ↗

Single-cell Profiling Uncovers a Muc4 -Expressing Metaplastic Gastric Cell Type Sustained by Helicobacter pylori -driven InflammationSemantic proximity Read ↗

Stem Cells, Helicobacter pylori, and Mutational Landscape: Utility of Preclinical Models to Understand Carcinogenesis and to Direct Management of Gastric Cancer.Semantic proximity Read ↗

Recapitulating Human Gastric Cancer Pathogenesis: Experimental Models of Gastric Cancer.Semantic proximity Read ↗

Comparison of gastric inflammation and metaplasia induced by Helicobacter pylori or Helicobacter felis colonization in miceSemantic proximity Read ↗

<i>Tff2</i> marks gastric corpus progenitors that give rise to pyloric metaplasia/SPEM following injurySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.