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Article

Tumor suppressor p53 and its gain-of-function mutants in cancer.

Acta biochimica et biophysica Sinica - 1 Mar 2014

Liu Juan, Zhang Cen, Feng Zhaohui

Abstract excerpt

Tumor suppressor p53 plays a pivotal role in tumor suppression. p53 is the most frequently mutated gene in cancer. As a transcription factor, p53 mainly exerts its role in tumor suppression through transcriptional regulation of its downstream target genes. Thus, p53 and its target genes form a complex p53 signaling pathway to regulate a wide variety of biological processes to prevent tumorigenesis. Recent studies...

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Identifiers

PMID: 24374774
DOI: 10.1093/abbs/gmt144
PMCID: PMC3932832

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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