Article
How mutations shape p53 interactions with the genome to promote tumorigenesis and drug resistance.
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy - 1 May 2018
Stiewe Thorsten, Haran Tali E
Abstract excerpt
The tumor suppressive transcription factor p53 regulates a wide array of cellular processes that confer upon cells an essential protection against cancer development. Wild-type p53 regulates gene expression by directly binding to DNA in a sequence-specific manner. p53 missense mutations are the most common mutations in malignant cells and can be regarded as synonymous with anticancer drug resistance and poor...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.