Article
Sex-specific role for adenylyl cyclase type 7 in alcohol dependence.
Biological psychiatry - 1 Jun 2011
Desrivières Sylvane, Pronko Sergey P, Lourdusamy Anbarasu, Ducci Francesca, Hoffman Paula L, Wodarz Norbert, Ridinger Monika, Rietschel Marcella, Zelenika Diana, Lathrop Mark, Schumann Gunter, Tabakoff Boris
Abstract excerpt
BACKGROUND: Alcohol has been shown to critically modulate cyclic adenosine-3',5' monophosphate (cAMP) signaling. A number of downstream effectors that respond to the cAMP signals (e.g., protein kinase A, cAMP response element binding protein) have, in turn, been examined in relation to alcohol consumption. These studies did not, however, delineate the point at which the actions of alcohol on the cAMP cascade...
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