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TNF‐α enhances apoptosis by promoting chop expression in nucleus pulposus cells: role of the MAPK and NF‐κB pathways

17 Dec 2018

Abstract excerpt

CHOP has been shown to be involved in AF cells apoptosis and disc degeneration in a rat model. The aim of this study was to investigate the regulatory effects of TNF-α on C/EBP homologous protein (CHOP) and the role of CHOP in nucleus pulposus (NP) cell apoptosis. The effects of TNF-α on chop were measured by qPCR, Western blot, and immunofluorescence. TNF receptor involvement was analyzed by small interfering...

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PMID: 30561076
DOI: 10.1002/jor.24204

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