Article

Expression of miR-195 and its target gene Bcl-2 in human intervertebral disc degeneration and their effects on nucleus pulposus cell apoptosis

2021-01-28

Abstract excerpt

<h4>Objective: </h4> To investigate the expression of miR-195 and its target gene Bcl-2 in intervertebral disc degeneration (IVDD) and its effect on nucleus pulposus (NP) cell apoptosis. <h4>Methods: </h4>: The expressions of miR-195 and Bcl-2 in NP tissues of IVDD patients were quantified by qRT-PCR and Western blotting, respectively. NP cells were divided into Blank group, TNF-α group, TNF-α + miR-NC group, TNF-...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f52c11ad-214b-5d25-a274-7c2d892dd4bd
DOI: 10.21203/rs.3.rs-69943/v2

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Expression of miR-195 and its target gene Bcl-2 in human intervertebral disc degeneration and their effects on nucleus pulposus cell apoptosisDOI 10.21203/rs.3.rs-69943/v2Read

miR‐328‐5p Induces Human Intervertebral Disc Degeneration by Targeting WWP2Semantic proximity Read

Causes of and Molecular Targets for the Treatment of Intervertebral Disc Degeneration: A ReviewSemantic proximity Read

Knockout of miR-17-92 Cluster Protect Against Intervertebral Disc Degeneration by Inhibiting Apoptosis of Nucleus Pulposus Cells in Mice via the Activation of PI3K/Akt PathwaySemantic proximity Read

Down‐regulation of insulin‐like growth factor binding protein 5 is involved in intervertebral disc degeneration via the ERK signalling pathwaySemantic proximity Read

tsRNA-04002 alleviates intervertebral disk degeneration by targeting PRKCA to inhibit apoptosis of nucleus pulposus cellsSemantic proximity Read

Role of microRNAs in intervertebral disc degeneration (Review)Semantic proximity Read

MicroRNA-140-3p alleviates intervertebral disc degeneration via KLF5/N-cadherin/MDM2/Slug axisSemantic proximity Read

MicroRNA-338-3p as A Novel Therapeutic Target for Intervertebral Disc DegenerationSemantic proximity Read

miR-188-5p delays intervertebral disc degeneration by mediating P4HB to regulate ferroptosis in nucleus pulposus cellsSemantic proximity Read

Vitamin D inhibits TNF-α induced apoptosis of human nucleus pulposus cells through regulation of NF-kB signaling pathwaySemantic proximity Read

A Bioinformatic Analysis of MicroRNAs’ Role in Human Intervertebral Disc DegenerationSemantic proximity Read

Circular RNA hsa_circ_0001658 Inhibits Intervertebral Disc Degeneration Development by Regulating hsa-miR-181c-5p/FASSemantic proximity Read