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HIF-2α induces aggravated intervertebral disc degeneration by activating the IL-6/hepcidin-FPN1 axis and promoting ferroptosis in nucleus pulposus cells

2025-11-10

Abstract excerpt

<title>Abstract</title> <p>Background Intervertebral disc degeneration (IVDD) is one of the main causes of spinal diseases and chronic low back pain. Nucleus pulposus (NP) cells are in a hypoxic environment, and their functions may be regulated by the hypoxia-inducible factor (HIF) family. In recent years, ferroptosis has been confirmed to be closely related to IVDD. HIF-2α plays a key role in hypoxic response, b...

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Literature Corpus work
fb17ea54-4a53-5eaa-b4ab-945cce9a7d0c
DOI
10.21203/rs.3.rs-7559424/v1
Open publication

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