Article
BRAF alterations are associated with complex mutational profiles in malignant melanoma.
Oncogene - 5 Aug 2004
Daniotti Maria, Oggionni Maria, Ranzani Tiziana, Vallacchi Viviana, Campi Valentina, Di Stasi Delia, Torre Gabriella Della, Perrone Federica, Luoni Chiara, Suardi Simona, Frattini Milo, Pilotti Silvana, Anichini Andrea, Tragni Gabrina, Parmiani Giorgio, Pierotti Marco A, Rodolfo Monica
Abstract excerpt
To evaluate the mutational profiles associated with BRAF mutations in human melanoma, we have studied BRAF, RAS, PTEN, TP53, CDKN2A and CDK4 genes and their expression in melanoma lesions. Owing to the lack of sufficient material from fresh specimens, we employed short-term cell lines obtained from melanoma biopsies. In all, 41 melanoma obtained from eight primary lesions, 20 nodal, 11 cutaneous and two visceral...
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