Article
Comparative study on driver mutations in primary and metastatic melanomas at a single Japanese institute: A clue for intra- and inter-tumor heterogeneity.
Journal of dermatological science - 1 Jan 2017
Kaji Tatsuya, Yamasaki Osamu, Takata Minoru, Otsuka Masaki, Hamada Toshihisa, Morizane Shin, Asagoe Kenji, Yanai Hiroyuki, Hirai Yoji, Umemura Hiroshi, Iwatsuki Keiji
Abstract excerpt
BACKGROUND: Searching for driver mutations in melanoma is critical to understanding melanoma genesis, progression and response to therapy. OBJECTIVES: We aimed to investigate the frequency and pattern of driver mutations in Japanese primary and metastatic melanomas including cases of unknown primary origin, in relation to their clinicopathologic manifestations. METHODS: Seventy-seven samples from 60 patients with...
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