Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Increased frequency of germline BRCA2 mutations associates with prostate cancer metastasis in a racially diverse patient population

12 Dec 2018

Abstract excerpt

BACKGROUND: Germline mutations in BRCA2 have been linked to a higher risk of prostate cancer (PCa), and high frequency of BRCA1 and BRCA2 (BRCA1/2) gene alterations was recently reported in metastatic castration-resistant PCa specimens. Mutations in BRCA2 vary in racial and ethnic groups including African-American (AA) and Caucasian-American (CA) populations. METHODS: BRCA1 and BRCA2 genes were sequenced (Ion...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to BRCA gene mutations in cancer
Share to PARP inhibition in cancer therapy
Share to Prostate Cancer Treatment and Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30542053
DOI: 10.1038/s41391-018-0114-1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Increased frequency of germline BRCA2 mutations associates with prostate cancer metastasis in a racially diverse patient populationPMID 30542053Read ↗

Metastatic prostate cancer is associated with distinct higher frequency of genetic mutations at diagnosis.Semantic proximity Read ↗

Characteristics of BRCA2 Mutated Prostate Cancer at Presentation.Semantic proximity Read ↗

Germline BRCA2 mutations drive prostate cancers with distinct evolutionary trajectories.Semantic proximity Read ↗

Genetic Contribution to Metastatic Prostate Cancer.Semantic proximity Read ↗

BRCA-deficient metastatic prostate cancer has an adverse prognosis and distinct genomic phenotype.Semantic proximity Read ↗

Germline variants in early and late-onset Brazilian prostate cancer patients.Semantic proximity Read ↗

Germline BRCA mutations are associated with higher risk of nodal involvement, distant metastasis, and poor survival outcomes in prostate cancer.Semantic proximity Read ↗

CDKN1B Deletions are Associated with Metastasis in African American Men with Clinically Localized, Surgically Treated Prostate CancerSemantic proximity Read ↗

Analysis of BRCA Germline Mutations in Chinese Prostate Cancer PatientsSemantic proximity Read ↗

Germline DNA Damage Repair Variants and Prognosis of Patients with High-Risk or Metastatic Prostate Cancer.Semantic proximity Read ↗

BRCA1 and BRCA2 pathogenic variants and prostate cancer risk: systematic review and meta-analysis.Semantic proximity Read ↗

Pathogenic germline variants in a racially diverse real-world cohort of prostate cancer patientsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.